At age 11, he was orphaned by his father's death from addiction and overdose. Afterwards he kept exploring audiovisual media and building small structures as imaginary worlds for escape. In 2009 he began his approach in printmaking with special attention to woodcutting and engraving, at the School of Fine Arts of the University of Puerto Rico, Río Piedras.
In his body of work he reflects on the world of the dead as a necessary and repetitive affair that collaborates reciprocally with life in motion. His interest in exploring ancestral experiences, rituals and the subconscious is evident, revealing a visual language hidden in the shapes. Uziel Orlandi Alegría works on these themes in a variety of media: engraving, xerographic transfer, wood, paper, photography, textile art, comics, animations, graphic design, encaustic, theatrical costumes, and ceramic sculpture, among others.